Engineering Exercise...
For the use intended (street) a single is more practical.
Electromotive used twin-turbo on the ZX for IMSA competition the first year, but went with a single unit for their all-conquering run in the 82-83 season.
Same for the Porsche, they thought the two turbos would respond better.
There are advantages, as the masses are something you can figure, smaller diameter wheels, etc etc etc.
There are a lot of other items, though, like complexity, more parts, slightly more difficult control.
For applications below a HP number, a single is simply more practical. If you are upwards of 400, then you can stat making arguments justifying Twins, as there are commercially available units that can be had fairly inexpensively, that will actually lower the cost of the setup, compared to the cost of a several-thousand dollar turbo unit.
Spool up is not really a factor, in a properly designed single setup, BTW.
Progressive setups are something altogether different!