The mixture nut determines the position of the jet tube. Tightening the nut moves the jet tube up which puts it on the fatter part of the needle so less gas leaks past the needle == Lean. Loosening the nut moves the jet tube down to a thinner part of the needle so that makes the mixture Richer.
You tighten them up to the top just to have a starting point of reference. Usually you can then loosen them 2 to 3 turns and you will be in the ballpark (assuming your timing, valves, idle screws, ignition etc are close to correct) enough to get the car idling. Then you use your air flow meter (or color tune, or ear, or wideband O2, or dyno, or plug color or butt dyno or voodoo) to get the mixture dialed in and the carbs balanced properly. ZTherapy has a good site and video to get you going.
Good Luck!
You tighten them up to the top just to have a starting point of reference. Usually you can then loosen them 2 to 3 turns and you will be in the ballpark (assuming your timing, valves, idle screws, ignition etc are close to correct) enough to get the car idling. Then you use your air flow meter (or color tune, or ear, or wideband O2, or dyno, or plug color or butt dyno or voodoo) to get the mixture dialed in and the carbs balanced properly. ZTherapy has a good site and video to get you going.
Good Luck!